As with other penicillins, side-effects are rare and usually of a mild and transitory nature.
Allergic reactions may occur, and these are normally mild in nature, presenting as a pruritic skin rash, an erythematous skin reaction or urticaria. In this event withdrawal of this drug and administration of an antihistamine will suffice in most cases. Should a serious anaphylactic reaction occur, the drug should be discontinued and the patient treated with the usual agents: (adrenaline, corticosteroids and antihistamines). Treatment with this drug may give rise to a maculopapular rash during therapy or within a few days after completion thereof. The incidence of maculopapular rash is especially high in patients suffering from infectious mononucleosis.
The use of this antibiotic may lead to the appearance of resistant strains of organisms and sensitivity testing should, therefore, be carried out wherever possible, to ensure the appropriateness of the therapy.
Hepatitis and cholestatic jaundice have been reported rarely.
Effects on ability to drive and use machines: No special precautions need to be taken.